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Molecular Hydrogen Therapy: Science, Benefits & Safety | Aquela H2 Library

Discover How Hydrogen Gas (H₂) Works as a Selective Antioxidant for Modern Health

aquela 8.0 hydrogen water
Molecular Hydrogen therapy

What is Molecular Hydrogen Therapy?

Molecular hydrogen (H₂) is the smallest, lightest molecule in the universe, with groundbreaking potential for health and wellness. Hydrogen therapy leverages H₂’s unique ability to neutralize harmful free radicals, reduce inflammation, and support cellular repair—all with no reported side effects. At Aquela, we combine cutting-edge research with practical solutions like hydrogen water sachets, clinical inhalation generators, and hydrogen bath systems.

Key Benefits of Molecular Hydrogen Therapy

✅ Selective Antioxidant Power
H₂ targets only the most damaging reactive oxygen species (ROS), unlike conventional antioxidants that disrupt beneficial signaling molecules.

✅ Deep Cellular Penetration
Due to its tiny size, hydrogen gas easily crosses the blood-brain barrier and reaches mitochondria for whole-body therapy.

✅ Clinically Proven Safety
Used since 1945 in deep-sea diving and naturally produced by gut microbiota, H₂ is non-toxic even at high concentrations.

The Science Behind Hydrogen Therapy

  • Antioxidant Mechanism: Neutralizes hydroxyl radicals (•OH) and peroxynitrite (ONOO⁻) linked to chronic inflammation.
  • Anti-Inflammatory Effects: Modulates NF-κB and NLRP3 pathways, reducing cytokine production (Ishibashi et al., 2012).
  • Metabolic Support: Enhances glucose metabolism and mitochondrial function (Sakai et al., 2014).
  • 1975: Dole et al. proposed hyperbaric hydrogen for cancer therapy (Read Study).
  • 2007: Ohsawa et al. identified H₂’s selective antioxidant role in Nature Medicine (Study Summary).
  • 2020s: Over 500 studies validate H₂ for conditions from arthritis to cognitive decline.
  • Hydrogen Water: Aquela’s 12ppm sachets for daily antioxidant support.
  • Inhalation Therapy: Clinical-grade H₂ gas for deep systemic benefits.
  • Hydrogen Baths: Topical H₂ infusion for skin and muscle recovery Ideal for Spas.

Is Molecular Hydrogen Safe?

  • Non-Toxic: Rated 0/0/0 on the Hazardous Material Information System when dissolved in water.
  • Rapid Clearance: Breath tests show H₂ returns to baseline levels within 60 minutes (Shimouchi et al., 2009).
  • Gut-Produced: Humans naturally generate H₂ via gut microbiota, confirming biocompatibility.

Applications of Hydrogen Therapy

🔹 Chronic Conditions

  • Rheumatoid arthritis (Ishibashi et al., 2012)
  • Psoriasis (Ishibashi et al., 2015)
  • Metabolic syndrome (Sakai et al., 2014)

🔹 Performance & Recovery

  • Post-workout muscle soreness
  • Cognitive fatigue

🔹 Aesthetic & Wellness

  • Skin detoxification via hydrogen baths
  • Anti-aging cellular support

Endogenous Intestinal Gas

The safety of molecular hydrogen is further supported by its presence in the human gastrointestinal tract, where it is produced by the gut microbiota alongside other gases like oxygen, nitrogen, carbon dioxide, methane, and hydrogen. This principle underlies the breath hydrogen test, a diagnostic tool for small intestinal bacterial overgrowth. Explore the foundational research. The natural production of hydrogen in the gut highlights its compatibility with human physiology, reinforcing its safety and potential as a therapeutic agent.

Expanding Applications in Modern Medicine

As research progresses, the applications of molecular hydrogen continue to expand. From its role in managing chronic diseases such as diabetes and cardiovascular conditions to its potential in enhancing cognitive function and protecting against neurodegenerative diseases, hydrogen therapy is becoming an integral part of modern medical practice. Its ability to selectively target harmful free radicals while sparing beneficial ones makes it a promising candidate for personalized medicine and preventative health strategies.

Frequently Asked Questions About Aquela Hydrogen Products

A biochemist and a Nobel prize nominee, Dr. Garth Nicolson describes molecular hydrogen as the best of all antioxidants and advocates the use of molecular hydrogen in beauty, fitness and health.

Here, we have compiled some of the most frequently asked questions about Aquela 8.0 and hydrogen water.

Hydrogen water is water infused with hydrogen gas (H2), the first element on the periodic table. Hydrogen water is different from water containing hydrogen ion (H+), the amount of which is used as a measure of acidity.

The saturation concentration of hydrogen gas in water is about 1.6 ppm, 1.6 mg/liter or 0.8 mM under normal conditions. It is nearly two million times higher than hydrogen concentration in natural water, because little hydrogen gas is present in the atmosphere.

A biochemist and a Nobel prize nominee, Dr. Garth Nicolson describes molecular hydrogen as the best antioxidant of all and advocates the use of molecular hydrogen in beauty, fitness and health. His group published a review article in 2016, pointing out several important facts concerning molecular hydrogen (1). [link to article] He also spoke about the potential benefits of molecular hydrogen in YouTube (Thermo Medica), which we believe is one of the best educational materials for the public.

We are affiliated with researchers and clinical physicians conducting research into the potential benefits of molecular hydrogen. Please read H2 Library  or contact us for more information on the status of the research.

Aquela 8.0 generates pure hydrogen gas and produces record-breaking 8 ppm, super saturated hydrogen water without affecting the pH and/or taste of the source water.

Aquela 8.0 uses a patented technology (PCT application in January 2018). Water permeates through its sachet membrane and reacts with ingredients (aluminium powder and calcium hydroxide). Amazingly, nothing comes out of the sachet, except for pure hydrogen gas.

No side effect has been reported in more than 40 clinical studies on the potential benefits of molecular hydrogen. There are several explanations for this result. Please read H2 Library or contact us for more information.

Half a litre of Aquela 8.0 hydrogen water contains 4 mg of molecular hydrogen. It is nearly 10 times more than the molecular hydrogen content in many hydrogen water products: i.e. 1.6 ppm, saturated hydrogen water in a 250 ml container contains 0.4 mg of molecular hydrogen.

Molecular hydrogen is administered through (a) oral ingestion of hydrogen gas enriched water, (b) inhalation of hydrogen gas, (c) intravenous injection of hydrogen gas enriched saline, and (d) transcutaneous application of hydrogen gas enriched water and other solutions.

Hydrogen gas inhalation is probably the preferred mode of molecular hydrogen administration in the clinical settings. However, the concentration of molecular hydrogen needs to be controlled between 2 – 4 %, otherwise, hydrogen gas inhalation can pose significant health and safety risks.

Aquela 8.0 and its predecessor, Aquela 7.0, have been used in clinical studies. We will continue our efforts to elucidate the potential benefits of molecular hydrogen; however, we believe that Aquela 8.0 is the safest and easiest way to bring molecular hydrogen into your everyday living.

Aquela 8.0 is registered as a food or nutrition supplement in the United Kingdom. It is manufactured at the state-of-the-art GMP facility and conforms to the stringent safety and quality guidelines in the United Kingdom. GMP stands for Good Manufacturing Practice and are the practices required to conform to the guidelines for the manufacturing and sales of pharmaceutical and supplement products.

We will continue clinical studies in collaboration with researchers and clinical physicians around the world. It is our hope that, one day, we will be able to register Aquela 8.0 as medicine.

Aquela 8.0 hydrogen water tastes just like normal water. It generates pure hydrogen gas, which is colourless, odourless and tasteless and affects neither taste nor pH of water.

Further studies are required to develop the effective daily intake guideline for molecular hydrogen. If we follow Dr. Toru Ishibashi’s suggestion in his book on anti-ageing (2016), however, the daily intakes of 3.5 – 4 mg H2 (one bottle of Aquela 8.0) would be the ideal amount for health maintenance.

Hydrogen gas is classified as a flammable gas. However, it does not ignite unless the temperature exceeds 527oC and its concentration in air exceeds 4 % in volume. When dissolved in water, hydrogen gas has a rating of 0/0/0 for health /flammability /instability on the Hazardous Material Information System.

Yes, you can chill, or add flavour to, Aquela 8.0 hydrogen water. However, this is only after enough hydrogen gas is produced – this means after 24 hours of putting the sachet in the bottle in most cases.

It is important to know that sugar and a number of other organic compounds prevent Aquela 8.0 from generating hydrogen gas, and that only the beverages with near neutral pH is suitable for the use with Aquela 8.0.

One example of such beverages is tea. However, please remember that tea may stain the bottle, and that tea has to be chilled to room temperature before the use with Aquela 8.0.

It is easy to make hydrogen water. You can dissolve hydrogen gas into water at a high pressure. Alternatively, you can produce hydrogen water by electrolysing water or by dissolving alkaline earth metal compounds. However, these processes turn the pH of water to alkaline and are not entirely free of chemical by-products.

Hydrogen is the smallest element in the known universe. Because of this, hydrogen gas can penetrate through the wall of plastic containers and escape through the seal of aluminum cans and pouches.

Japanese scientists led research into the potential benefits of molecular hydrogen. Consequently, the market is flooded with hydrogen water products in both plastic and aluminum containers. In 2015, the Japanese Consumers Affairs Bureau tested the hydrogen concentration in those products, finding that they did not contain as much hydrogen as their label claimed.

A simple answer to the questions is, “Make hydrogen water and drink it as soon as practical.”

Generally, hydrogen concentration is reduced from 8 ppm to approximately 4 ppm over a 1-hour period at room temperature after opening the bottle.

A portion of hydrogen gas escapes from the water, when you transfer the water to a cup or glass. The same happens when you swirl or agitate the water after opening the bottle.

The speed of the chemical reaction in the sachet depends largely on water temperature. At room temperature between 15 – 25oC, however, you can drink Aquela 8.0 hydrogen water after 24 hours.

It is more than 4,400 ppm, 4,400 mg/liter or 100 mM. This tells you that hydrogen gas does not dissolve in water as much as carbon dioxide (CO2) does.

REFERENCES

  1. Ishibashi, T. et al., 2012. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patient with rheumatoid arthritis: an open-label pilot study. Medical Gas Research, 2: 27. 
  2. Sakai, T. et al., 2014. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vascular Health and Risk Management: 10: 591-597.
  3. Ishibashi, T. et al., 2015. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Molecular Medicine Reports, 12: 2757-2764. 
  4. Nicolson, G.L. et al., 2016. Clinical effects of hydrogen administration: From animal and human diseases to exercise medicine. International Journal of Clinical Medicine, 7: 32-76.
  5. Dixon & Zhang, 2016. An Innovative collection in hydrogen molecular biology and medicine research. Medical Gas Research, 6: 55-56.
  6. Dole, M. et al., 1975. Hyperbaric hydrogen therapy: a possible treatment for cancer. Science, 190: 152-154.
  7. Shirahata, S. et al., 1997. Electrolyzed-reduced water scavenges active oxygen species　and protects DNA from oxidative damage. Biochemical and Biophysical Research　 234: 269-274.
  8. Ohsawa, M. et al., 2007. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13: 688-694.
  9. Ge, L. et al., 2017. Molecular hydrogen a preventive and therapeutic medical gas for various diseases. Oncotarget, 8: 102653-102673.
  10. Shimouchi, A. et al., 2009. Breath hydrogen produced by ingestion of commercial hydrogen water and milk. Biomarker Insights, 4: 27-32.
  11. Abraini, J.H. et al., 1994. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. Journal of Applied Physiology, American Physiological Society, 76: 1113-1118. 
  12. Newcomer, A.D. et al., 1975. Prospective comparison of indirect methods for detecting lactase deficiency. New England Journal of Medicine, 293: 1232-1236.
  13. Metz, G. et al., 1976. Breath-hydrogen test for small-intestinal bacterial colonisation. Lancet, 1: 668-669.
  14. Rhodes, J.M. et al., 1979. The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Scandinavian Journal of Gastroenterology, 14:333

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Contact us today to learn more about Aquela 8.0 and our innovative hydrogen therapy solutions. We’re excited to partner with you on your wellness journey!

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