“A significant pro-inflammatory condition is observed in the lung of patients with severe COVID-19. Neutrophilic asthma (type 2 low) and chronic obstructive pulmonary disease share similar inflammatory signatures to the severe case of COVID-19.”

“The H2 inhalation therapy shows a promise against this chronic airway inflammation”.

What does COVID-19 do to the lungs?

The leading cause of mortality in patients with COVID-19 is hypoxic respiratory failure from acute respiratory distress syndrome. This is accompanied with:

What did the hydrogen gas inhalation therapy achieve in treating COVID-19 patients?

The H2 inhalation therapy ameliorated dyspnea and decreased respiratory tract resistance in adults and children.

Guan, W-J. et al., 2020. Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnoea in patients with coronavirus disease 2019 in a recent multi-center, open-label clinical trial. Journal of Thoracic Disease, 12: 3448-3452.

The H2 inhalation therapy led to a significant decrease in neutrophil percentage and the concentration and abnormal proportion of C- reactive protein.

What does COVID-19 do to the lungs in the long term?

In a systematic review, 22·6% of people, who required hospital admission, and 20·4% of people, who did not require hospital admission, reported persistent dyspnoea or breathlessness.

The damage to the alveolar–capillary interface has been observed in people with persistent dyspnoea 6 months after COVID-19.

Singh, S.J. et al., 2023. Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical care and rehabilitation. The Lancet Respiratory Medicine, In Press.

Is hydrogen gas inhalation therapy beneficial in the rehabilitation of COVID-19 patients?

Current rehabilitation strategies to manage post-COVID-19 breathlessness are limited. Recent studies show the potential benefit of H2 inhalation therapy in rehabilitating COVID-19 patients.

Botek, M. et al., 2022. Molecular hydrogen positively affects physical and respiratory function in acute post-COVID-19 patients: A new perspective in rehabilitation. International Journal of Environmental Research and Public Health, 19: 1992.

Hydrogen gas inhalation therapy may be beneficial in the treatment of asthma and chronic obstructive pulmonary disease.

A single inhalation of H2 for 45 min attenuated inflammatory status in airways in patients with asthma and COPD.

Wang, S-T. et al., 2020. Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients. QJM International Journal of Medicine, 113: 870-875.

The H2/O2 inhalation therapy is superior to the O2 inhalation therapy in patients with acute exacerbation of chronic obstructive pulmonary disease with acceptable safety and tolerability profile.

Zheng, Z-G. et al., 2021. Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group trial. Respiratory Research, 22: 149.

Asthma & COPD

Asthma is typically classified into high inflammation (eosinophilic) and low inflammation (neutrophilic). These two types of asthma are equal in terms of prevalence, though certain ambiguities remain.

Neutrophilic asthma shares similar features to chronic obstructive pulmonary disease (COPD). It is important to note that the treatment options for neutrophilic asthma and COPD are limited.

Wan, R. et al., 2023. Cellular senescence in asthma: from pathogenesis to therapeutic challenges. The Lancet EBioMedicine, 94: 104717.

The H2 inhalation therapy is giving hope to patients with asthma and COPD.

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